Nasal/ear drops, 2% solution.

Main physicochemical properties: brown solution with slight opalescence.

Pharmacotherapeutic group.

Means used in diseases of the nose. Anti-edematous and other means for local use in diseases of the nose. Other means for the treatment of nasal diseases. ATX code R01A X10.

Pharmacodynamics.Antibacterial agent. Preparations of silver proteinate, ions or silver salts inhibit the growth of gram-positive and gram-negative bacteria (bacteriostatic effect). In addition, silver ions determine the precipitation of bacterial proteins (bactericidal effect).

Pharmacokinetics.

Locally applied silver proteinate is poorly absorbed.

Clinical characteristics:

Indication.

Anti-edematous and antiseptic agent for the mucous membrane of the nose and antiseptic for the ear canal.

Hypersensitivity to any substance included in the medicinal product.

Interaction with other medicinal products and other types of interactions.

Protargol can interact with drugs that contain papain.

Papain is a proteolytic enzyme that belongs to the class of hydrolases and is extracted from unripe papaya fruits (Carica papaya). Simultaneous use of silver proteinate and papain can reduce the enzyme action of the latter.

Avoid simultaneous use with drugs based on papaya (see the section “Interaction with other drugs and other types of interactions”). You should follow the recommended doses and method of use of the medicinal product. Silver proteinate can cause toxic effects when used excessively over a long period of time.

Use during pregnancy or breastfeeding.

Pregnancy

There are insufficient data on the use of silver proteinate in pregnant women. Silver proteinate should not be used during pregnancy, unless absolutely necessary.Breast-feeding

There are insufficient data on the use of silver proteinate during breastfeeding. Silver proteinate should not be used during breastfeeding, unless absolutely necessary.

The ability to influence the speed of reaction when driving vehicles or other mechanisms.

Does not affect.

Enter 1-2 drops in each nostril or in the ear canal 2-3 times a day. The course of treatment is 5–10 days.

Children.

The drug is not intended for use by children.

Overdose.

In case of an overdose, which is associated with the accumulation of high concentrations of silver ions in the blood plasma, the skin may become discolored and slurred speech may occur. Accumulation of silver in the skin, mucous membranes, membranes and in the eyes, which is associated with long-term use of the drug, can cause an allergy, the characteristic feature of which is the coloring of the skin in a color from gray to dark blue, which is caused by the interaction of silver with various proteins and, as a result, the production of pigments. In addition, systemic symptoms may occur, such as hepatotoxicity, cardiomyopathy, amnesia, which are a consequence of the neurotoxicity process.

Data on determining the frequency of individual listed effects are not availableency of individual listed effects are not available.