Active ingredients: streptokinase, streptodornase. 1 suppository contains streptokinase 15000 IU, streptodornase 1250 IU. Excipients: mineral oil, solid fat.

Main physical and chemical properties: Cylindrically-conical suppositories of white to beige colour. Air-porous core and dimple-like pits are allowed on the cut.

Pharmacodynamics

SK-SD, streptokinase-streptodornase, suppositories, works locally after rectal administration. Streptokinase acts as a fibrinolytic and dissolves fibrin and other clots. Streptodornase dissolves deoxyribonucleoproteins and deoxyribonucleic acids, resulting in a decrease in the viscosity of purulent exudates and dissolution of dead cells.

Pharmacokinetics

Streptokinase and streptodornase act locally on blood clots, purulent and necrotic parts of cells and tissues. The medicine is administered rectally and is not absorbed into the bloodstream.

The streptokinase-plasminogen complex is gradually converted to polypeptides. The decomposition products, together with other substrate fragments, are mechanically removed. After DNA polymerisation, streptodornase is converted into a nucleotide mixture and mechanically removed with parts of dead cells.

• Hypersensitivity to the active substances or excipients of the drug;
• presence of a fresh wound, surgical suture or bleeding up to 10 days (this may cause loosening of the sutures and, as a result, bleeding from the wound);
• simultaneous use with anticoagulants, which may lead to local bleeding;
• blood clotting disorders.

The medicine may cause local irritation.

The effect of SK-SD, streptokinase-streptodornase on fertility, pregnancy and lactation has not been studied.

Ability to influence the reaction rate when driving vehicles or using other mechanisms.

It does not affect the ability to influence the reaction rate when driving or using other mechanisms.

SK-SD, streptokinase-streptodornase is contraindicated for use with anticoagulants, as bleeding may occur.

Direction of administration

Rectally. Suppositories should be inserted deep into the rectum, after removing the suppository from the blister. Wash hands thoroughly before and after using the drug.

Dosage

Course of treatment: 4–18 suppositories. Duration of the course: 2–9 days. The dosage is prescribed by the doctor in accordance with the intensity of the inflammatory process.

In severe and chronic course of the disease:

• 1 suppository 3 times a day for the first 3 days;
• 1 suppository 2 times a day for the next 3 days;
• 1 suppository 1 time a day for the next 3 days.

Course of treatment: 9 days, 18 suppositories.

In moderate course of the disease:

• 1 suppository 2 times a day for the first 3 days;
• 1 suppository 1 time a day for the next 4 days,

Course of treatment – ​​7 days, 10 suppositories.

In mild cases:

• 1 suppository 2 times a day for 2 days.

Course of treatment: 2 days, 4 suppositories.

In the absence of results or in the event of relapse, the doctor must determine the need for a second course of treatment.

The medicine may cause local irritation.

Use during pregnancy and breastfeeding.

The effect of SK-SD, streptokinase-streptodornase on fertility, pregnancy and lactation has not been studied.

Ability to influence the reaction rate when driving vehicles or using other mechanisms.

It does not affect the ability to influence the reaction rate when driving or using other mechanisms.

Store at 2-8 °C in the original packaging. Do not freeze.

Keep out of the reach of children.

There are no data on overdose of streptokinase and streptodornase.

Occasionally, local pain, swelling or minor bleeding, irritation, diarrhoea, allergic reactions, and fever may occur.

6 suppositories in a blister; 1, 2 or 3 blisters in a carton.

2 years.